Programs

ONE MIND has numerous projects at various stages of development. The following are our flagship initiatives, which have been in development for over a year and are positioned for full operational launch in 2013.

The annual cost of Mental Illness in the US is $1 Trillion - the human cost is PRICELESS.
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1 in 3 people will suffer brain illness or injury in their lifetime.
Brain diseases and injuries cost society as much as $2 TRILLION per year in the US and EU.
Brain disorders and injuries cost society more than cancer and cardiovascular disease COMBINED.
1.7 MILLION Americans have Autism.
1.7 MILLION Americans suffer a Traumatic Brain Injury every year.
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Traumatic Brain Injury (TBI) is one of the LEADING CAUSES OF DEATH AND DISABILITY in America.
53,000 Americans die every year due to Traumatic Brain Injury.
8 teenagers die EVERY DAY in the US from TBI.
There are 5 MILLION Americans living with TBI-related disabilities.
5.3 MILLION Americans have lifelong disabilities due to Traumatic Brain Injury (TBI).
Direct and indirect cost of TBI is $76 BILLION per year in the US.
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Nearly 8% of the US population suffers from POST-TRAUMATIC STRESS in their lifetime.
300,000 soldiers suffer TBI and/or PTS.
There is 1 military suicide per day in the US.
FOUR people commit suicide EVERY HOUR in the United States.
90% of suicide victims have a TREATABLE MENTAL DISORDER.
Nearly 10% of people with SCHIZOPHRENIA commit suicide.
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Number one sport per capita for traumatic brain injury is GIRLS SOCCER.
HALF A MILLION children under 14 go to the emergency room every year for TBI.
Funding for brain research from government and pharmaceutical companies is DECREASING EVERY YEAR.
Someone develops Alzheimer’s Disease EVERY 68 SECONDS.
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Over 5 million Americans have Alzheimer’s Disease.
Medicaid and Medicare spend $130 BILLION per year on Alzheimer’s patients.
Over 400,000 Americans have Multiple Sclerosis.
The lowest rates of Multiple Sclerosis are in countries nearest to the EQUATOR.
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DEPRESSION is the LEADING CAUSE of disease burden in the U.S.
Nearly 7% of American adults had a MAJOR DEPRESSIVE EPISODE in the past 12 months.
Over 2 MILLION Americans over the age of 18 suffer from BIPOLAR DISORDER.
Over 2 MILLION Americans have SCHIZOPHRENIA.
The annual medical cost of Schizophrenia in the US is OVER $32B.

Programs

Programs

THE GEMINI PROJECT

Knowledge Integration Network (KIN) for Traumatic Brain Injury (TBI) and Post- Traumatic Stress (PTS)

GEMINI is a Public-Private Partnership combining best-in-class science, technology, and expertise. One Mind is catalyzing collaboration between international research Centers of Excellence, Industry, and government to accelerate the translation of basic science into breakthrough diagnostics and improved treatments for TBI & PTS.

TBI affects an estimated 10 million people worldwide and more than 1.7 million in the U.S. TBI is a silent epidemic--its complications are frequently invisible, thus difficult to diagnose and treat. TBI can lead to motor, cognitive, and social impairments that interfere with an individual’s ability to be productive.

PTS is a severe anxiety disorder that follows an event that causes psychological trauma. Early evidence suggests that as many as 20% of the approximately 1.64 million U.S. troops returning from deployments to Afghanistan and Iraq show symptoms of PTS or major depression. The psychological toll of multiple deployments--many involving prolonged exposure to combat-related stress--is high compared with physical injuries.

The GEMINI PROJECT TBI-PTS Knowledge Integration Network will accelerate advancements in diagnosis and treatment for veterans and civilians alike.

In 2013, One Mind will launch this multi-country, multi-site initiative to create a large-scale database of individuals with acute head trauma and/or psychological trauma with rigorous biomarker (e.g. genetics, imaging) and clinical measures to:

  • Identify biological indicators of the causes and effects of diseases, or pathology.
  • Investigate disease progression for earlier, more accurate diagnosis and treatment.

BRAIN DATA EXCHANGE PORTAL

One Mind, in partnership with the International Neuroinformatics Coordinating Facility and other partners, is creating a digital environment for multiple-source data sharing, with open analysis tools, and provenance tracking systems for working with complex data. This system will foster an unprecedented open science approach among academia, industry, non-profits, and governments that will remove the barriers to effective scientific and clinical research and speed diagnosis and treatment.

VIRTUAL BIOREPOSITORY PROGRAM

A dynamic, on-line international registry of brain-related disorder biorepositories supported by the Neuroscience Information Framework (NIF), American Brain Coalition, and the NIH. Learn more at http://neuinfo.org/onemind

ORION BIONETWORKS: MULTIPLE SCLEROSIS

One Mind has joined the Orion Bionetworks Alliance for Multiple Sclerosis. Orion is a program of the Marin Community Fund, a non-profit 501(c)(3) corporation. Orion Bionetworks is a multidisciplinary computational modeling community that is harnessing the power of data, technology, and collaboration to pave the way for Systems Medicine and transform the research and treatment of multiple sclerosis and other brain disorders.

Orion Bionetworks Mission

We are developing causal disease models with unprecedented predictive power that will drive progress towards better treatments and, ultimately, cures for multiple sclerosis and other devastating brain disorders.

To advance the understanding of brain disorders, Orion Bionetworks is building powerful, data-driven disease models.

  • To make real progress, we have to use systems biology to understand how numerous complex, nonlinear biological and patient factors interact to cause brain disorders. We are creating a framework to advance causal disease models using computational tools to integrate diverse biological and clinical data from registries and repositories.
  • These causal disease models will be continually refined and improved through collection of new high-dimensional, quality data and validated against real-world patient data.

A Unique Cooperative Alliance Model is enabling sustainable, multidisciplinary collaboration

  • No one entity has the full array of resources needed to advance the research and treatment of multiple sclerosis.
  • In the Orion BioNetwork, complementary stakeholders contribute patient data, expertise, computational models, IT capabilities or funds to support the coordinated development of next-generation models.
  • All partners have access to data contributed to the Data Commons through a Data Exchange Portal with Analytics Capabilities.